Regulation of DC development and DC-mediated T-cell immunity via CISH
نویسندگان
چکیده
Cytokine inducible SH2-containing protein (CISH) plays a crucial role in type 1 dendritic cell (DC) development as well as in the DC-mediated activation of cytotoxic T lymphocytes (CTLs). CISH expression at late DC developmental stages shuts down the proliferation of DC progenitors by negatively regulating signal transducer and activator of transcription 5 (STAT5) and facilitates the differentiation of DCs into potent stimulators of CTLs.
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2013